Preclinical Studies of a Kidney Safe Iodinated Contrast Agent
نویسندگان
چکیده
منابع مشابه
Preclinical Studies of a Kidney Safe Iodinated Contrast Agent
BACKGROUND AND PURPOSE Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the use of iodinated contrast agents. This problem is particularly acute in interventional neurology and interventional cardiology, probably due to the intra-arterial route of injection, high contrast volumes, and preexisting risk factors of these patients. In an attempt to develop a contrast agent...
متن کاملDoes safe dosing of iodinated contrast prevent contrast-induced acute kidney injury?
BACKGROUND Previous work on contrast-induced acute kidney injury (CI-AKI) has identified contrast volume as a risk factor and suggested that there is a maximum allowable contrast dose (MACD) above which the risk of CI-AKI is markedly increased. We hypothesized that there is a relationship between contrast volume and CI-AKI and that there might be reason to track incremental contrast volumes abo...
متن کاملAcute kidney injury with iodinated contrast.
Diagnostic and interventional radiographic procedures in critically ill patients commonly depend on iodinated contrast media and consequently pose the risk of contrast-induced acute kidney injury. This is an important complication that accounts for a significant number of cases of hospital-acquired renal failure, with adverse effects on prognosis and healthcare costs. The epidemiology and patho...
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Iodinated contrast media (CM) are used in many investigations that a patient may undergo during the course of an in-patient stay. For the vast majority of patients, exposure to CM has no sequelae; however, in a small percentage, it can result in a worsening in renal function termed contrast-induced acute kidney injury (CI-AKI). CI-AKI is one of the leading causes of in-hospital renal dysfunctio...
متن کاملA liposomal nanoscale contrast agent for preclinical CT in mice.
OBJECTIVE The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a murine model. MATERIALS AND METHODS A second-generation, liposomal blood pool contrast agent encapsulating a high concentration of iodine (83-105 mg I/mL) was evaluated. A total of five mice weighing between 20 and 28 ...
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ژورنال
عنوان ژورنال: Journal of Neuroimaging
سال: 2016
ISSN: 1051-2284
DOI: 10.1111/jon.12356